WebJul 17, 2007 · The human Thoc1 gene, also known as hHpr1 or p84, encodes a protein that was originally identified as a nuclear matrix component that binds the retinoblastoma … Clinical data analysis was performed to explore the function of THOC1 in HCC. The representative images of immunohistochemistry downloaded from The Human Protein Atlas database indicated that the THOC1 expression was higher in tumors than that in normal liver tissues (Fig. 1a). Similarly, the clinical … See more THOC1 was knocked down or overexpressed in HCC cell lines to further verify its effect. Western blot analysis results indicated that THOC1 expression was … See more THOC1 can promote HCC cell proliferation in vitro. Hence, we further investigated the in vivo tumorigenic ability of THOC1. The tumors derived from PLC/PRF/5 cells … See more Based on the structure of THOC1, lead compounds with high docking scores to THOC1 were selected from the traditional Chinese medicine database by virtual … See more
Expression of THOC1 in cancer - Summary - The Human Protein …
WebTHOC1 (HPR1, P84) protein expression summary. We use cookies to enhance the usability of our website. ... BMC Cancer 2011;11:77: Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers Domínguez-Sánchez MS et al BMC Cancer 2011;11:77: ANTIGEN INFORMATION; WebDec 4, 2015 · The THO complex 1 (Thoc1) is a nuclear matrix protein playing vital roles in transcription elongation and mRNA export. Recently, aberrant expression of Thoc1 has been reported in an increasing array of tumor types. However, the clinical significance of Thoc1 expression in colorectal cancer (CRC) is still unknown. data visualisation gss
Elevated expression of Thoc1 is associated with ... - ScienceDirect
WebJul 15, 2013 · The expression of thoc1 was suppressed in bladder cancer cells (MBT-2) co-cultured with CCL-34-activated macrophages, whereas treatment with an iNOS inhibitor could restore the expression of thoc1. Direct treatment of MBT-2 cells with an NO donor also repressed thoc1 expression. WebHepatocellular carcinoma (HCC) is one of the most common malignant cancers with poor prognosis and high incidence. The clinical data analysis of liver hepatocellular carcinoma samples downloaded from The Cancer Genome Atlas reveals that the THO Complex 1 (THOC1) is remarkable upregulated in HCC and associated with poor prognosis. However, … WebJan 10, 2014 · Furthermore, the knockdown of THOC1 or THOC5 did not cause apoptosis in normal cells, but it causes apoptosis in cancer cells [25, 27, 49]. In addition, recent data imply the involvement of THOC5 in leukemia development . These data suggest that members of THO complex could be a target molecule for cancer therapy. maschio italian