WebMay 1, 2011 · Pandolfi PP, Paolo Pinton Search articles by 'Paolo Pinton' Pinton P Author information Affiliations 1 author 1. Department of Experimental and Diagnostic Medicine; Section of General Pathology; Interdisciplinary Center for the Study of Inflammation (ICSI) and LTTA Center; University of Ferrara; Ferrara, Italy. ORCIDs linked to this article WebDec 12, 1992 · Pp Pandolfi, M. Alcalay, M. Fagioli, et al. Genomic variability and alternative splicings generate multiple PML/RARα transcripts that encode aberrant PML proteins and PML/RARα isoforms in acute promyelocytic leukaemias EMBO J, 11 ( 1992), pp. 1397 - 1407 CrossRef View in Scopus Google Scholar 5 A. Biondi, A. Rambaldi, Pp Pandolfi, et al.
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WebOct 30, 2014 · Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder that manifests with hemolytic anemia, bone marrow failure, and thrombosis. 1-4 One of the earliest descriptions of PNH was by Dr Paul Strübing, who in 1882 described a 29-year-old man who presented with fatigue, abdominal pain, and … Pier Paolo Pandolfi is an Italian doctor, geneticist, molecular biologist, and cancer researcher.
WebJan 16, 2014 · These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. WebNational Center for Biotechnology Information
WebThe p53 tumor suppressor promotes cell cycle arrest or apoptosis in response to stress. Previous work suggests that the promyelocytic leukemia gene (PML) can act upstream of p53 to enhance transcription of p53 targets by recruiting p53 to nuclear bodies (NBs). http://www.hostedfileshere.com/pandolfi_lab/team.html
WebGan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol 2024; 22:246-256. PubMed
WebApr 4, 2011 · Bernardi R,Papa A,Pandolfi PP.Regulation of apoptosis by PML and the PML-NBs.Oncogene. 2008;27:6299-312. Google Scholar. Salomoni P,Pandolfi PP.The role of PML in tumor suppression.Cell. 2002;108:165-70. Google Scholar. Lin HK,Bergmann S,Pandolfi PP.Cytoplasmic PML function in TGF-beta signalling. connectwise offlineWebJul 2, 2015 · and Pier Paolo Pandolfi, M.D., Ph.D. In addition to heredity and the environment, chance may also play a role in the development of cancer. Because the acquisition of mutations is stochastic... connectwise office 365 email connectorWebThe cyclin dependent kinase inhibitor p27 plays an important role in controlling the eukaryotic cell cycle by regulating progression through G1 and entry into S phase. It is often elevated during differentiation and under conditions of cellular stress. connectwise office locationsWebDec 16, 2009 · Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumour suppression. Nature Genetics. 1998; 19:348–355. doi: 10.1038/1235. [Google Scholar] 37. Wu X, Obata T, Khan Q, Highshaw RA, De Vere White R, Sweeney C. The phosphatidylinositol-3 kinase pathway regulates bladder … connectwise oncallWebPandolfi PP, Grignani F, Alcalay M, Mencarelli A, Biondi A, LoCoco F, Grignani F, Pelicci PG. Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene. 1991 Jul; 6 (7):1285–1292. [Google Scholar] Petkovich M, Brand NJ, Krust A, Chambon P. connectwise office tampaWebPandolfi PP, Roth ME, Karis A, Leonard MW, Dzierzak E, Grosveld FG, Engel JD, Lindenbaum MH. Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat Genet. 1995 Sep; 11 (1):40–44. [Google Scholar] Wurster AL, Siu G, Leiden JM, Hedrick SM. connectwise number of employeesWebFeb 4, 2024 · Diagnosis was confirmed by the identification of NPM1 mutation A and FLT3 -ITD (ratio 0.9). The BM karyotype was normal. The patient received a 7+3 induction regimen, achieving CR and only a 1.7-log reduction of NPM1 mut transcripts, with FLT3 -ITD still detectable with a ratio of 0.01. connectwise office 365