Diversity-oriented synthesis
http://www-spring.ch.cam.ac.uk/publications/pdf/2013_DOS_1.pdf WebDiversity-Oriented Synthesis of Chemically Recyclable Poly(sulfonamide ester)s through Organocatalytic Aziridine-Based Multicomponent Polymerization . Songjie Fan, Peng Zhu, Jintong Ye, Huishan Huang, Zhen Zhang and Jinxiang Dong Abstract. Aziridine is a highly reactive strained ring that allows the synthesis of diverse small molecules. ...
Diversity-oriented synthesis
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WebMar 7, 2011 · Diversity-oriented synthesis (DOS) is an approach toward small-molecule library synthesis, which seeks to achieve this goal (9, 10, 13, 27). The overall aim of a … WebJul 13, 2024 · Advanced Synthesis & Catalysis. Volume 360, Issue 19 p. 3655-3661. Communication. Diversity-Oriented Synthesis of Functionalized Imidazopyridine Analogues with Anti-Cancer Activity through a Transition-Metal Free, One-pot Cascade Reaction. Gui-Ting Song, Gui-Ting Song.
WebDiversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial … WebSince our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space and …
Webinteracting with preselected protein targets [called target-oriented synthesis (TOS)] and those libraries used in “efforts to identify simultaneously therapeutic protein Diversity … WebFeb 7, 2024 · Herein we report the first versatile and expeditious method for the site-selective C–H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the diversity-oriented synthesis (DOS) of fluoromethylated arenes. This methodology features the use of the low-cost industrial …
http://www-spring.ch.cam.ac.uk/publications/pdf/2013_DOS_1.pdf
WebDiversity-Oriented Synthesis represents the synthesis of relatively small libraries of organic molecules that are structurally more complex, have a greater variety of core … lasten avaruusretkiWebOct 12, 2024 · Inspired by its inherent highly congested functional groups, a secologanin-based diversity-oriented synthesis (DOS) strategy for novel pseudo-natural alkaloids was developed. All the reactive units of secologanin were involved in these operation simplicity protocols under mild reaction conditions, including the one-step enantioselective ... lasten avaruus kirjatWebApr 7, 2024 · The catalyst-controlled diversity-oriented synthesis of spirohydroquinoline-indandiones and 3-methylenehydroquinoline-indandiones from ortho-sufonamidophenyl … lasten avaruus elokuvaWebMar 7, 2011 · Diversity-oriented synthesis (DOS) is an approach toward small-molecule library synthesis, which seeks to achieve this goal (9, 10, 13, 27). The overall aim of a DOS is to efficiently generate a library of small molecules with a high degree of structural, and thus functional, diversity that interrogates large areas of chemical space (9, 28). lasten avaruusseikkailuWebMar 30, 2024 · Herein, we reported the first versatile and expeditious protocol for the diversity-oriented synthesis (DOS) of fluoroalkylated amines via the photoinduced … lasten avohoitoyksikkö taysWebOct 15, 2024 · Diversity-oriented synthesis and its role in ‘bioactive’ discovery. As its name implies, one of the primary goals of DOS is to achieve efficient syntheses of structurally diverse collections of small molecules. To realize this aim, series of complexity-generating transformations (e.g. cycloadditions and multicomponent reactions) are ... lasten avaruus ohjelmaWebThe Derek Tan Lab: Research Overview. The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design as ... lasten avaruuslaulu