Web3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta GA 30322, USA *Equal contribution Correspondence to: Qiang Wu; email: [email protected] Keywords: long non-coding RNA H19, atherosclerosis, CCCTC-binding factor, polycystic kidney disease 1, atherosclerotic vulnerable plaque formation WebSep 7, 2024 · Topologically associating domains (TADs), CTCF loop domains, and A/B compartments have been identified as important structural and functional components of 3D chromatin organization, yet the relationship between these features is not well understood. ... 1 Department of Biology, Emory University, 1510 Clifton Road Northeast, Atlanta, GA …
The Role of CTCF in Cell Differentiation - Emory University
WebAnalysis of chromatin accessibility in sperm of the F1–F6 generations reveals alterations at sites containing binding motifs for CCCTC-binding factor (CTCF) at two cis-regulatory elements (CREs) of the Fto gene that correlate with transmission of obesity. http://www.biology.emory.edu/research/Corces/assets/a-ctcf-code-for-3d-genome-architecture.pdf strategies for reaching all students elm 555
Drosophila CTCF tandemly aligns with other insulator ... - Emory …
WebMar 22, 2024 · CTCF is a zinc-finger protein that was initially described as a transcriptional repressor of the Myc gene ( Klenova et al., 1993; Lobanenkov et al., 1990 ). It is conserved among bilaterians, and phylogenetic analyses suggest an early origin in the evolution of Metazoa ( Heger et al., 2012 ). WebThe DNA is arranged in a specific manner in the 3D space of the nucleus. This arrangement is partly a consequence of the transcriptional state of the chromatin. In addition, the CTCF protein and the cohesin complex for … WebAug 8, 2015 · CTCF is a DNA-binding protein known to play a variety of roles in the regulation of transcription by forming loops in which distant elements of the genome are brought into spatial proximity within the nucleus (Ong and Corces, 2014).The formation of these loops is believed to involve homodimerization of the CTCF proteins bound to their … strategies for reactive attachment disorder